Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter

AE Morgan, SP Porter, FA Clarkson, ND Volkow… - Synapse, 1997 - Wiley Online Library
… has been aimed at the development of a vaccine designed to prevent cocaine from entering
… the direct and indirect approaches is to attenuate cocaine’s ability to increase extracellular

Dopamine reuptake transporter (DAT)“inverse agonism”–a novel hypothesis to explain the enigmatic pharmacology of cocaine

DJ Heal, J Gosden, SL Smith - Neuropharmacology, 2014 - Elsevier
effect of cocaine and methylphenidate is not attenuated by DAT … are not mediated by blockade
of dopamine reuptake. … increases in extracellular dopamine with no dose-effect ceiling to …

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

C Saunders, JV Ferrer, L Shi, J Chen… - Proceedings of the …, 2000 - National Acad Sciences
… The dopamine transporter (DAT) is a target of amphetamine (… modulating the cytotoxic
effects of elevated extracellular DA. … this effect was significantly attenuated by coincubation with …

Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys

HL Kimmel, JA Nye, R Voll, J Mun, J Stehouwer… - Synapse, 2012 - Wiley Online Library
… Since, the effects of cocaine are impulse-dependent; … attenuating the effects of cocaine,
even if cocaine was still bound to DAT. In the current studies, we did not measure cocaine levels …

Regulation of dopamine transporter by phosphorylation and impact on cocaine action

RA Vaughan - Cerebral Signal Transduction: From First to Fourth …, 2000 - Springer
… The availability of extracellular dopamine for dopaminergic … are all targets for the
psychostimulant drug cocaine. The drug … transport for loss or attenuation of protein-kinase-induced …

The dopamine transporter expression level differentially affects responses to cocaine and amphetamine

B Cagniard, TD Sotnikova, RR Gainetdinov… - Journal of …, 2014 - Taylor & Francis
… both cocaine and amphetamine mainly target the dopamine … mice, cocaine-induced increase
in extracellular dopamine had a … expression was significantly attenuated in constitutive DAT …

Chemogenetic manipulation of dopamine neurons dictates cocaine potency at distal dopamine transporters

ZD Brodnik, W Xu, A Batra… - Journal of …, 2020 - Soc Neuroscience
… We next examined whether selective activation of somatodendritic DREADDs impacts cocaine
potency at distal DATs in the NAc. We implanted bilateral cannulae targeted to the VTA of …

Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter

MEA Reith, BE Blough, WC Hong, KT Jones… - Drug and alcohol …, 2015 - Elsevier
… and inhibit dopamine uptake but do not share cocaine-like effects. … (eg, cocaine and
methylphenidate), including attenuatedEffects of DAT releasers on extracellular dopamine (DA) …

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

B Giros, M Jaber, SR Jones, RM Wightman, MG Caron - Nature, 1996 - nature.com
… The dopamine transporter is an obligatory target of cocaine … can be attenuated by selective
dopamine receptor … system by increasing DA concentrations in the extracellular space and …

Dopamine transporter as target for drug development of cocaine dependence medications

AK Dutta, S Zhang, R Kolhatkar, MEA Reith - European journal of …, 2003 - Elsevier
… It has been shown that GBR 12909 can attenuate the increase in extracellular dopamine
induced by cocaine as measured in microdialysis experiments in rat brain, which might indicate …